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Endothelial cells (EC) and endothelial precursor cells (EPC) kinetics in hematological patients undergoing chemotherapy or autologous stem cell transplantation (ASCT).

We have previously demonstrated that hearts from streptozotocin-treated rats are almost entirely dependent on fatty acid β-oxidation as a source of TCA cycle acetyl CoA when perfused with glucose and palmitate as working hearts with either diabetic or normal substrate concentrations ().

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Do Angiotensin-converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Have Similar Effects in the Improvement of Left Ventricular Dysfunction after Myocardial Infarction in Japanese?

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Comparison of thallium-201 exercise SPECT and dobutamine stress echocardiography for diagnosis of coronary artery disease in patients with left bundle branch block.

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We observed that 3 mo of metoprolol treatment in dogs with coronary microembolization-induced heart failure improved LV function and a significant 28% decrease in CPT-I activity (), suggesting that the shift in substrate metabolism observed in the clinical studies could be due to downregulation of this enzyme.

Pauses are associated with a poor prognosis in patients with CAD and left ventricular dysfunction.

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At equivalent, noncompeting concentrations, in isolated working rat hearts, the oxidation of unsaturated fatty acids such as oleate () or arachidonic acid () occurs at similar rates to that of the saturated fatty acid palmitate.

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Life-table analysis that was based on intention to treat and that included all deaths revealed no difference between the prazosin and placebo groups ( Figure 1 Cumulative Mortality from the Time of Randomization in the Three Treatment Groups.

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We extend the previous findings by showing that trimetazidine (1) improves left ventricular function in patients with chronic heart failure caused by nonischemic dilated cardiomyopathy; (2) reduces myocardial free fatty acid oxidation by only 10% in the failing human heart, raising the possibility of additional mechanisms of action; (3) has whole-body metabolic effects, with increased insulin sensitivity potentially linked to decreased whole-body free fatty acid oxidation; and (4) unexpectedly improves circulating lipid profile by increasing high-density lipoprotein cholesterol levels by 11%.

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