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The first and last authors designed the trial in collaboration with the clinical development team at the Immune Tolerance Network and clinical investigators of the RAVE research group.
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No symptoms were reported by any health care worker in this study.
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NABPs inhibit toll-like receptor (TLRs) activation and subsequent cytokine production of dendritic cells and B cells.
In comparison, patients who are chronically exposed to low levels of inhaled antigens can develop subtle interstitial inflammatory reactions in the lung that do not result in noticeable symptoms for months to years; these patients present with severe, impairing disease, which can be very difficult to distinguish from IPF.
From these it became clear that, based on the improved CR rate and its associated PFS benefit in the CTD-treated patients and with further follow up, the survival benefit would likely increase, equating to a 3% improvement in survival at nine years.
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For other analyses, two-sample comparisons were performed with the use of Student's t-test or a Wilcoxon rank-sum test for continuous measures and a chi-square test or Fisher's exact test for binary measures.
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