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This may be the result of: (1) excessive secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland, which may actually result from faulty release of corticotropin-releasing factor from the hypothalamus; (2) tumor of the adrenal cortex, causing hypersecretion of the glucocorticoids; (3) ectopic production of ACTH by extrapituitary tumors, most commonly lung carcinoma, medullary thyroid carcinoma, and thymoma; and (4) iatrogenic Cushing's syndrome resulting from overzealous administration of exogenous glucocorticoids.

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Magnetic Resonance Imaging (MRI): This technique is useful when a pituitary mass is present and it's size is not discernable via other imaging techniques.

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