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Those with fl at spots or clean-based ulcers do not require endoscopic therapy or intensive intravenous PPI therapy.

Nonetheless, recent data indicate that, compared with placebo or H 2RAs, PPIs significantly reduce mortality in some patient subgroups, including Asian populations and patients with high-risk endoscopic findings.

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Following an overnight fast, test medication was administered and patients were given a light meal within 15 minutes.

Pantoprazole sodium delayed-release tablets may affect how other medicines work, and other medicines may affect how pantoprazole sodium delayed-release tablets works.

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High dose pantoprazole and somatostatin continuous iv infusion are equally effective to suppress intragastric pH after endoscopic haemostasis in patients with a peptic ulcer bleeding.

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Several medications are sometimes used to speed the process such as antibiotics or steroids but there is little evidence that these medications are effective.

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Pilotto A, Leandro G, Franceschi M, Bierti L, Di Battista R, Notarbartolo A, Pisciotta G, Grassi A, Crestani B, Tafner G, Michelagnoli S "Rapid improvement of symptomatology with pantoprazole, amoxycillin and metronidazole in Helicobacter pylori-positive duodenal ulcer patients.

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Data reported are only for omeprazole and they suggest that, until it is possible to rule out an association between PPIs and an increased risk of fetal malformations or preterm birth, the benefit of using a PPI during pregnancy must be weighted against the potential risk for the fetus ().

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Esomeprazole 20 mg od has also been shown to be more effective in maintaining healing of erosive GERD compared to lansoprazole 15 mg od or pantoprazole 20 mg od.

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FIGURE 1 illustrates the distribution of doses determined to be appropriate or inappropriate given the indication and patientspecific factors from this internal review.

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