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Ropinirole is a nonergoline dopamine D(2)-receptor agonist and has been proven to be effective in both monotherapy and combination therapy for idiopathic Parkinson's disease.

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Among these therapies are standard physical, occupational, and speech therapies, which help with gait and voice disorders, tremors and rigidity, and decline in mental functions.

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It has already been suggested that this disorder is a manifestation of decreased dopamine activity at striatal dopamine receptors and that such decreased activity results in most patients from decreased dopamine released from nigrostriatal dopaminergic neurons: presynaptic dopamine deficiency.

After prolonged therapy with levodopa, a person with PD can alternate from phases with good response to medication and few symptoms (the “on” state), to phases with no response to medication and significant motor symptoms (the “off” state); therefore, levodopa doses are kept as low as possible after using alternatives such as dopamine agonists and MAO-B inhibitors.

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